碳酸锂对抗放化疗肿瘤患者遗传及氧化损伤作用的研究

doi:10.3969/j.issn.1004-616x.2002.02.009

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2002, Vol. 14 ›› Issue (2): 98-101.doi: 10.3969/j.issn.1004-616x.2002.02.009

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INHIBITORY EFFECT OF LITHIUM CARBONATE ON GENETIC AND OXIDATIVE DAMAGE IN CANCER PATIENTS WITH RADIOTHERAPY AND CHEMOTHERAPY

LUO Peng1; ZHANG Ai-hua1; LI Jun1, QING Du-cai2; REN Yu-jiang1; ZHAGN Bi-xia2; WANG Xi-lan1;HUANG Xiao-xing2

1. Dept. of Preventive Medicine, Guiyang Medical College, Guiyang 550004 , China; 2.44th Hospital of PLA, Guiyang 550009, China

Received:2001-04-23 Revised:2001-10-22 Online:2002-04-30 Published:2002-04-30
Contact: LUO Peng

Abstract

Abstract: Purpose : To observe the inhibitory effect of lithium carbonate (Li2CO3 ) on genetic and oxidative damage in cancer patients. Methods : The single cell gel elect rophoresis assay (SCGE) , micronucleus test were used to measure DNA and chromosomal damage. At the same time , SOD , GSH-Px , and2SH and MDA were detected by biochemical tests. Results : The genetic damage of peripheral blood cells in cancer patients was relieved gradually with Li2CO3 treatment , and the activity and content of the anti-oxidative material and WBC number increased significantly. Conclusion : Li2CO3 can inhibit genetic damage , increase the ability of anti-oxidation and relieve the myellogenic inhibition.

Key words: lithium carbonate, cancer patient, lymphocyte, genetic damage, oxidation damage

CLC Number:

R73 - 36

LUO Peng, ZHANG Ai-hua, LI Jun, QING Du-cai, REN Yu-jiang, ZHAGN Bi-xia, WANG Xi-lan, HUANG Xiao-xing. INHIBITORY EFFECT OF LITHIUM CARBONATE ON GENETIC AND OXIDATIVE DAMAGE IN CANCER PATIENTS WITH RADIOTHERAPY AND CHEMOTHERAPY[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2002, 14(2): 98-101.

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INHIBITORY EFFECT OF LITHIUM CARBONATE ON GENETIC AND OXIDATIVE DAMAGE IN CANCER PATIENTS WITH RADIOTHERAPY AND CHEMOTHERAPY

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